Abstract
The less than self-evident effect of alterations in cell kinetics on the growth of hemopoietic colonies in the spleens of irradiated mice has important implications for the interpretation of results obtained with this unique multipotential stem cell assay. The effect on colony growth of variation in the principle cell kinetic parameters has been calculated by simulating the growth of spleen colonies so as to provide a guide to the interpretation of experimental results. This data is used to re-interpret two particular experimental observations on the effect of cytotoxic agents in terms of alterations in the response of stem cells to regulatory factors in place of previous interpretations regarding the differing self-renewal capacities for subpopulations of stem cells and their sensitivity to various drugs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
