Abstract
The effect of 15 metal cations and NH + 4 on the response current of an inactive polypyrrole uricase electrode has been investigated. Uricase is activated only by Mn 2+ among the investigated cations. The response current of the uricase electrode increases with increasing the concentrations of Mn 2+ and uric acid. Based on the experimental fact, a mechanism of the activation kinetics of immobilized uricase in the presence of Mn 2+ is presented, that is, E + M ⇌ EM, EM + S ⇌ EMS → EM + P, and a rate equation from this model is given. The activation time of the immobilized uricase relates to an applied potential and less than 10s at potentials above 0.375 V.
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