Abstract
Glyburide is under investigation for treatment of gestational diabetes. The previously identified metabolites of glyburide were 4-trans (M1) and 3-cis (M2) hydroxycyclohexyl glyburide. Recently, we identified four additional metabolites formed by human and baboon liver and placental microsomes. Baboon is a primate that can be used when investigations in human are impossible. The aim of this work was to determine the apparent Km of glyburide and the rates for formation of each metabolite (Vmax) by microsomal preparations from human and baboon placentas and livers.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
