Abstract
Isolated canine kidneys were perfused with either calcium-containing or calcium-free media. These kidneys did not show appreciable biochemical or functional changes. Renal arteriograms at the conclusion of the perfusion revealed no abnormalities. Introduction of calcium ions following a calcium-free perfusion period resulted in immediate biochemical and functional alterations. This is termed “calcium paradox.” Arteriograms of these kidneys showed extensive extravasation of radiopaque dye, clearly illustrating damage to vessel walls. The importance of the presence of calcium ions in all kidney perfusion media is stressed.
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