The key scientific problems and translational research thoughts of intracerebral hemorrhage preventions and treatments

Abstract

Intracerebral hemorrhage (ICH) has features of high disability and high lethality, which is still lack for effective preventions and treatments. Therefore, it is urgent to focus on the key scientific problems facing the clinical treatment of ICH, and carry out basic clinical translational research from the key mechanism of occurrence and development, providing new ideas for ICH preventions and treatments. The previous theories about the pathogenesis of ICH are still need to be further explored. The use of modern gene sequencing and multi-omics methods is expected to reveal the whole picture of the pathogenesis of ICH. Hematoma formation and secondary brain damage are important to the development of ICH. Minimally invasive hematoma removal should be the first choice for ICH treatment in the future, but it is still necessary to push innovative clinical research from multiple disciplines such as treatment time window, treatment methods and radiography. Key words: Intracerebral hemorrhage; Endothelial cell; Minimal invasive surgery