Abstract
Nutritional ketosis is effective to contrast seizure disorders and other acute and chronic neurological disorders. Glucose is the primary metabolic fuel for cells, however many neurodegenerative disorders have been recently associated with impaired glucose transport and metabolism causing energy deficits, such as in Alzheimer’s disease, Parkinson’s disease, general seizure disorders, and traumatic brain injury. Ketone bodies and tricarboxylic acid cycle intermediates can bypass the rate-limiting steps associated with impaired neuronal glucose metabolism. After prolonged periods of fasting or ketogenic diet (KD), the body utilizes energy obtained from free fatty acids (FFAs) released from adipose tissue. Hepatic ketogenesis converts FFAs into ketone bodies-hydroxybutyrate and acetoacetate, while a percentage of acetoacetate spontaneously decarboxylates to acetone. This represents a state of normal physiological ketosis and can be therapeutic. Therapeutic ketosis leads to metabolic adaptations that may improve brain metabolism, restore mitochondrial ATP production, decrease reactive oxygen species production, reduce inflammation, and increase neurotrophic factors’ function. It has been shown that KD mimics the effects of fasting and the lack of glucose/insulin signaling, which promotes a metabolic shift towards fatty acid utilization. KD can only induce a modest blood ketone level elevation and requires extreme dietary carbohydrate restriction for maintaining sustained levels of ketosis. Prior to the advent of exogenous insulin for the treatment of diabetes mellitus in the 1920's, general guidelines for therapy were represented only by dietary modifications. For example, Dr. Elliot Joslin’s Diabetic Diet in 1923 consisted of meats, poultry, game, fish, clear soups, gelatin, eggs, butter, olive oil, coffee, tea and contained approximately 5% of energy from carbohydrates, 20% from protein, and 75% from fat. A similar diet was advocated by Dr. Frederick Allen. The aim of this work is to analyze the current literature on therapeutic ketosis and its successful clinical applications in diabetes type I and II.
Highlights
It has been shown that metabolic-based therapies, such as nutritional ketosis, are effective to contrast seizure disorders and various acute and chronic neurological disorders [1,2,3,4]
After prolonged periods of fasting or ketogenic diet (KD), the body utilizes energy obtained from free fatty acids (FFAs) released from adipose tissue
Therapeutic ketosis leads to metabolic adaptations that may improve brain metabolism, restore mitochondrial ATP production, decrease reactive oxygen species production, reduce inflammation, and increase neurotrophic factors’ function [12]
Summary
It has been shown that metabolic-based therapies, such as nutritional ketosis, are effective to contrast seizure disorders and various acute and chronic neurological disorders [1,2,3,4]. Ketone bodies and tricarboxylic acid cycle intermediates represent alternative fuels for the brain and can potentially bypass the rate-limiting steps associated with impaired neuronal glucose metabolism. Therapeutic ketosis (elevated blood ketone levels) can be considered as a metabolic therapy by providing alternative energy substrates, which may have potent cellular protective properties independent of their bioenergetic function [10]. Large quantities of ketone bodies accumulate in the blood (up to 5 mM) through this mechanism This represents a state of normal physiological ketosis and can be therapeutic. Diet recommendations aimed to control blood glucose (which in most cases was only glycosuria) and were dramatically different from current low-fat, high-carbohydrate dietary recommendations for patients with diabetes [15,16]. Paving the road towards a wider and safer use of this metabolic approach in these patients
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