Abstract
The family of potassium channel tetramerizationdomain (KCTD) proteins consists of 26 members with mostly unknown functions. The name of the protein family is due to the sequence similarity between the conserved N-terminal region of KCTD proteins and the tetramerization domain in some voltage-gated potassium channels. Dozens of publications suggest that KCTD proteins have roles in various biological processes and diseases. In this review, we summarize the character of Bric-a-brack,Tram-track, Broad complex(BTB) of KCTD proteins, their roles in the ubiquitination pathway, and the roles of KCTD mutants in diseases. Furthermore, we review potential downstream signaling pathways and discuss future studies that should be performed.
Highlights
The human potassium (K+) channel tetramerization domain (KCTD)family of proteins consists of 26 members that share sequence similarity with the cytoplasmic domain of voltage-gated K+ channels(Kv channels) [1,2,3]
There are some features of Potassium channel tetramerization domain (KCTD) that have not been reviewed in this article
The PDIP1 family members (KCTD10, KCTD13, and Tumor necrosis factor (TNFAIP1)) are tumor necrosis factor-a-inducible proteins that can stimulate the activity of DNA polymerase in DNA replication and repair pathways [48]
Summary
The human potassium (K+) channel tetramerization domain (KCTD)family of proteins consists of 26 members that share sequence similarity with the cytoplasmic domain of voltage-gated K+ channels(Kv channels) [1,2,3]. A variety of functions have been identified for the BTB domain-containing KCTD proteins. These functions include transcriptional repression [4,5], cytoskeleton regulation [6], tetramerization and gating of ion channels [7,8], and interaction with the cullin E3 (Cul3) ubiquitin ligase complex [9,10]. We will summarize the homology between KCTD family members and some of the key features of KCTD proteins.
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