The KCa2.3 potassium channel at 1q21 is associated with disease progression and reduced survival during relapse in multiple myeloma

Abstract

e226 Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece Efstathios Kastritis, Maria Gavriatopoulou equal contribution. Bone metabolism has not been systematically studied in primary (AL) amyloidosis. Thus, we prospectively evaluated bone remodeling indices in 102 patients with newly diagnosed AL amyloidosis, 35 healthy controls, 35 newly diagnosed myeloma and 40 MGUS patients. Bone resorption markers (CTX, NTX) and osteoclast regulators (sRANKL, osteoprotegerin(OPG) were increased in AL patients compared to controls (p 60 months; p1⁄40.012). We conclude that increased OPG in AL is not only a compensation to osteoclast activation, but may also reflect early cardiac damage and may identify patients at increased risk of death within those with earlier Mayo stage.