The Kaplan-Meier survival analysis of the dual sodium related comparative Jordanian critically ill cohorts whose major administered antibiotics were beta-lactams

Abstract

Background: Abnormal serum sodium levels in various diseases increase mortality; however, hyperglycemia depresses serum sodium concentration significantly. Aim: This study aimed to evaluate the clinical impact of measured serum sodium levels and corrected sodium levels among Jordanian critically ill cohorts whose major administered antibiotics were Beta-Lactams Methods: This study was retrospectively conducted in the Intensive Care Unit (ICU) to primarily investigated the 2 proposed Na-based prognosticators against the overall mortality for the admitted critically ill patients in the Intensive Care Unit (ICU) at the King Hussein Medical Center between Jan 2018 and May 2021, after approval by the Royal Medical Services, Jordan local Institutional Review Board committee (IRB). A Kaplan-Meier test was conducted on the tested critically ill patients to explore the "time-to-event" during their admission days in the ICU and to determine if there were differences in the survival distribution for the different types of the 2 investigated dual different Na-related comparative cohorts [Measured Na related Events Cohort vs Measured Na related Censored Cohort and Corrected Na related Event Cohort vs Corrected Na related Censored Cohort]. Also, the Survival Kaplan-Meier test was used to plot the Survival functions’ illustrations for each tested Na-related mortality prognosticator. Results: The survival distributions for the 2 investigated dual comparative cohorts were statistically significantly different [χ2 (3) = 30.454, p-value=0.000 and χ2 (2) = 23.411, p-value=0.000, respectively] at Mean±SEM overall LOS of [21.444±0.138 days (95% CI; 21.173-21.714) and 21.444±0.138 days (95% CI; 21.173-21.714), respectively] and Number (%) of both Event and Censored cohorts of [1715 (79.6%) vs 440 (20.4%), respectively]. Conclusion: Our study revealed that both the measured and corrected hyponatremia had significant prognostic performances regarding major clinical outcomes when critically ill patients were studied regardless of their blood levels.