The Janus of Oxidative Stress Signaling in Different Pathophysiological Conditions

Sumitra Miriyala,Meera Ramanujam,Aimee Landar,Manikandan Panchatcharam,Anantharaman Muthuswamy,Saurabh Chatterjee

doi:10.1155/2013/708796

Abstract

The Janus of Oxidative Stress Signaling in Different Pathophysiological Conditions

Highlights

Because of the dual role of reactive oxygen species (ROS) in cells in the production and removal of cellular ROS, a greater understanding of oxidative stress, under both normal and disease-causing conditions, and the involvement of cell organelle ROS in global regulation of gene expression can illuminate the contribution of mitochondria and other cell organelles in the development of disease and may lead to the advancement of new and novel therapeutic modalities that exploit oxidative stress in treating many diseases
Gorbunov et al propose that the cell survival mechanisms activated in lipopolysaccharide-treated mesenchymal stromal cells in vitro could be a part of adaptive responses employed by stromal cells under septic conditions
The results clearly show that radical flux exerts direct cytotoxic effects, decreases NO bioavailability, enhances lipid peroxidation, increases sympathetic activity, and activates the proinflammatory transcription factor NF-κB leading to the well-known clinical manifestations of obstructive sleep apnea in the cardiovascular disease system

Summary

Introduction

Editorial The Janus of Oxidative Stress Signaling in Different Pathophysiological Conditions Sumitra Miriyala,1 Manikandan Panchatcharam,1 Aimee Landar,2 Meera Ramanujam,3 Saurabh Chatterjee,4 and Anantharaman Muthuswamy5 Because of the dual role of ROS in cells in the production and removal of cellular ROS, a greater understanding of oxidative stress, under both normal and disease-causing conditions, and the involvement of cell organelle (mitochondrial, endoplasmic reticulum) ROS in global regulation of gene expression can illuminate the contribution of mitochondria and other cell organelles in the development of disease and may lead to the advancement of new and novel therapeutic modalities that exploit oxidative stress in treating many diseases.

Results

Conclusion