Abstract
BackgroundEpidemiological studies suggest a non-monotonic effect of alcohol consumption on cardiovascular risk, while there is strong evidence concerning the involvement of homocysteine levels on thrombosis. The aim of this work was to evaluate the association between usual ethanol consumption and homocysteine levels, in cardiovascular disease free adults.MethodsFrom May 2001 to December 2002 we randomly enrolled 1514 adult men and 1528 women, without any evidence of cardiovascular disease, stratified by age – gender (census 2001), from the greater area of Athens, Greece. Among the variables ascertained we measured the daily ethanol consumption and plasma homocysteine concentrations.ResultsData analysis revealed a J-shape association between ethanol intake (none, <12 gr, 12 – 24 gr, 25 – 48 gr, >48 gr per day) and total homocysteine levels (mean ± standard deviation) among males (13 ± 3 vs. 11 ± 3 vs. 14 ± 4 vs. 18 ± 5 vs. 19 ± 3 μmol/L, respectively, p < 0.01) and females (10 ± 4 vs. 9 ± 3 vs. 11 ± 3 vs. 15 ± 4 vs. 17 ± 3 μmol/L, respectively, p < 0.01), after controlling for several potential confounders. The lowest homocysteine concentrations were observed with ethanol intake of < 12 gr/day (Bonferroni α* < 0.05). No differences were observed when we stratified our analysis by type of alcoholic beverage consumed.ConclusionWe observed a J-shape relationship between homocysteine concentrations and the amount of ethanol usually consumed.
Highlights
ObjectivesThe aim of this work was to evaluate the association between usual ethanol consumption and homocysteine levels, in cardiovascular disease free adults
Epidemiological studies suggest a non-monotonic effect of alcohol consumption on cardiovascular risk, while there is strong evidence concerning the involvement of homocysteine levels on thrombosis
Middle-aged male participants (45 – 65 years old) consumed higher quantities of ethanol compared to younger (< 45 years) or older individuals (18 ± 16 vs. 12 ± 14 vs. 15 ± 16 gr of ethanol per day, respectively, p = 0.002), while no statistically significant differences were observed between ethanol consumption and age, in females (9 ± 13 vs. 11 ± 12 vs. 12 ± 14 gr of ethanol per day, respectively, p = 0.391)
Summary
The aim of this work was to evaluate the association between usual ethanol consumption and homocysteine levels, in cardiovascular disease free adults
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