Abstract
The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS ‘Guide to Receptors and Channels’ (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the ∼6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques.
Highlights
IntroductionOnline resources have become indispensable tools for pharmacology and drug discovery, in common with other disciplines in the biomedical sciences
Online resources have become indispensable tools for pharmacology and drug discovery, in common with other disciplines in the biomedical sciences. Databases such as ChEMBL [1] and PubChem [2] provide extensive information on the bioactivity and chemical structures of approved and experimental drugs and their interaction with targets, either manually curated from the medicinal chemistry literature (ChEMBL) or uploaded by depositors (PubChem). To complement these large-scale resources, there is a need for an in-depth, expert-curated overview of the key targets and ligands, to foster basic and clinical research and innovative drug discovery, and to educate the generation of researchers
We suggest that pharmacologically oriented users might find the curatorially selected set of stringent activity mappings in the Guide to PHARMACOLOGY a simpler entry point but we provide extensive linking to the other high-value resources
Summary
Online resources have become indispensable tools for pharmacology and drug discovery, in common with other disciplines in the biomedical sciences Databases such as ChEMBL [1] and PubChem [2] provide extensive information on the bioactivity and chemical structures of approved and experimental drugs and their interaction with targets, either manually curated from the medicinal chemistry literature (ChEMBL) or uploaded by depositors (PubChem). To complement these large-scale resources, there is a need for an in-depth, expert-curated overview of the key targets and ligands, to foster basic and clinical research and innovative drug discovery, and to educate the generation of researchers.
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