Abstract
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators. This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015. Our relationship matrix now describes ∼9000 ligands, ∼15 000 binding constants, ∼6000 papers and ∼1700 human proteins. As an important addition, we also introduce our newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org). This has been ‘forked’ from the well-established GtoPdb data model and expanded into new types of data related to the immune system and inflammatory processes. This includes new ligands, targets, pathways, cell types and diseases for which we are recruiting new IUPHAR expert committees. Designed as an immunopharmacological gateway, it also has an emphasis on potential therapeutic interventions.
Highlights
The International Union of Basic and Clinical Pharmacology/British Pharmacological Society IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) is an expert-curated resource of ligand–activity–target relationships, selected from high-quality pharmacological and medicinal chemistry literature
We have extended the database schema to group some ligands into families using the information on Hugo Gene Nomenclature Committee (HGNC) gene family pages [15,16]; examples include cytokines and chemokines
Clicking one of the top-level categories on the Processes panel displays a new page listing all targets associated with that process
Summary
The International Union of Basic and Clinical Pharmacology/British Pharmacological Society IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) is an expert-curated resource of ligand–activity–target relationships, selected from high-quality pharmacological and medicinal chemistry literature. To access SAR data for all targets, we point users to our download page (www.guidetopharmacology.org/download.jsp) where they can download a CSV file containing all interactions. The Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb) expansion has extended the database to incorporate data types relevant to immunopharmacology, and associate these with existing target and ligand entities.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
