Abstract
THE ISOLATION OF FORMALDEHYDE FROM DIMETHYLAMINOETHANOL, DIMETHYLGLYCINE, SARCOSINE, AND METHANOL
Highlights
With the potassium phosphate buffer, which more closely resembles the intracellular fluid of liver than does Serensen’s buffer, formaldehyde was isolated in higher yields from both dimethylglycine and sarcosine
Formaldehyde has been isolated, as the dimedon derivative, from dimethylaminoethanol, dimethylglycine, sarcosine, and methanol incubated with liver homogenates prepared in buffer
Formaldehyde was isolated when methanol was incubated with the supernatant fraction alone or when dimethylglycine and sarcosine were incubated with the washed sediment
Summary
In concomitant experiments [2] it was shown that sarcosine is a metabolite in the animal body, its methyl carbon being derived from methyl groups ingested in the form of methionine or betaine. Some 10 years earlier, Handler, Bernheim, and Klein [3] had observed an increased oxygen uptake and a positive color test for formaldehyde when sarcosine and dimethylglycine were incubated with a washed liver sediment. They reported that sarcosine was not oxidized by a similar preparation obtained from kidney.
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