Abstract
A common chromosomal abnormality, del (3) (p14-p23) has been described in small cell lung carcinoma (SCLC). This abnormality occurs only in tumor cells, and the SCLC cells typically contain one or more apparently normal copies of chromosome 3. Unfortunately, there have been reports of heterogeneity with different SCLC tumors. However, in the midst of this “deleted region” exists a common fragile site that recently has been reported as the most active fragile site in the human genome. In the absence of molecular probes for the specific chromosome breakpoints involved in SCLG, I have chosen to saturate human chromosome 3 with molecular probes and to use these probes to begin a molecular dissection of the region spanning 3pl4-p23.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
