Abstract
Isolation and identification of the major degradation products of flurandrenolide occurring in its commercially marketed cream base are reported. The syntheses of these agents are described. An extraction procedure and reversed-phase HPLC assay are presented, the basis of the assay being separatior of acidic degradation products using an ion pairing agent. Comparison of the HPLC assay with the blue tetrazolium (BT) assay showed the Chromatographie assay to be superior to the colonmetric assay. This was principally due to a major degradation product giving a positive response to the B.T. assay. The major degradation products observed were the C 20-aldehyde of flurandrenolide along with the C 20-carboxylic acid and the C17-carboxylic acid.
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