Abstract
Lipid extracts of lungs of sheep, guinea pig, monkey and man were analyzed for smooth muscle stimulating substances. Most of the spasmogenic activity was due to prostaglandins. After preliminary purification the prostaglandins were isolated and identified with silicic acid chromatography, reversed phase partition chromatography, layer chromatography and gas liquid chromatography. Prostaglandin F 2α (PGF 2α) was the main prostaglandin present and was identified in all lungs. Approximate concentrations of PGF 2α g wet wt. calculated by means of isotope dilution were; sheep lung 0.5 μg, guinea pig lung 0.5 μg, human lung (autopsy material) 0.02 μg, monkey lung (autopsy material) 0.2 μg. Prostaglandin E 2 was identified in sheep lung.
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