Abstract
AbstractThe efficient and selective oxidation of secondary CH sites of alkanes is achieved by using low catalyst loadings of a non‐expensive, readily available iron catalyst [Fe(II)(CF3SO3)2(mcp)], {Fe‐mcp, [mcp=N,N′‐dimethyl‐N,N′‐bis(2‐pyridylmethyl)cyclohexane‐trans‐1,2‐diamine]}, and hydrogen peroxide (H2O2) as oxidant, via a simple reaction protocol. Natural products are selectively oxidized and isolated in synthetically amenable yields. The easy access to large quantities of the catalyst and the simplicity of the CH oxidation procedure make this system a particularly convenient tool to carry out alkane CH oxidation reactions on the preparative scale, and in short reaction times.magnified image
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