Abstract
The extent of population structure within Ireland is largely unknown, as is the impact of historical migrations. Here we illustrate fine-scale genetic structure across Ireland that follows geographic boundaries and present evidence of admixture events into Ireland. Utilising the ‘Irish DNA Atlas’, a cohort (n = 194) of Irish individuals with four generations of ancestry linked to specific regions in Ireland, in combination with 2,039 individuals from the Peoples of the British Isles dataset, we show that the Irish population can be divided in 10 distinct geographically stratified genetic clusters; seven of ‘Gaelic’ Irish ancestry, and three of shared Irish-British ancestry. In addition we observe a major genetic barrier to the north of Ireland in Ulster. Using a reference of 6,760 European individuals and two ancient Irish genomes, we demonstrate high levels of North-West French-like and West Norwegian-like ancestry within Ireland. We show that that our ‘Gaelic’ Irish clusters present homogenous levels of ancient Irish ancestries. We additionally detect admixture events that provide evidence of Norse-Viking gene flow into Ireland, and reflect the Ulster Plantations. Our work informs both on Irish history, as well as the study of Mendelian and complex disease genetics involving populations of Irish ancestry.
Highlights
The extent of population structure within Ireland is largely unknown, as is the impact of historical migrations
The results of the principal component analysis (PCA) of the fineStructure co-ancestry matrix are shown in Supplementary Data 3 and Supplementary Fig. 2
We have investigated population structure and diversity within Ireland with high-density genome-wide SNP data of 192 individuals with four generations of Irish ancestry from specific regions around Ireland
Summary
The extent of population structure within Ireland is largely unknown, as is the impact of historical migrations. We illustrate fine-scale genetic structure across Ireland that follows geographic boundaries and present evidence of admixture events into Ireland. We detect admixture events that provide evidence of Norse-Viking gene flow into Ireland, and reflect the Ulster Plantations. Our work informs both on Irish history, as well as the study of Mendelian and complex disease genetics involving populations of Irish ancestry. There have since been a number of significant historical migrations into Ireland; the Norse Vikings in the late first millennium[8], the Norman invasion of the 12th century[9], and the Plantations of the 16th and 17th centuries[9] The impact of these migrations on the modern Irish genome is largely unknown. The extent of such structure across the island of Ireland is unknown, and such a description would facilitate disease gene mapping within Ireland, as well as complementing similar efforts involving populations with Irish ancestry[21,22,23]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.