Abstract
The Immuno Polymorphism Database (IPD) was developed to provide a centralized system for the study of polymorphism in genes of the immune system. Through the IPD project we have established a central platform for the curation and publication of locus-specific databases involved either directly or related to the function of the Major Histocompatibility Complex in a number of different species. We have collaborated with specialist groups or nomenclature committees that curate the individual sections before they are submitted to IPD for online publication. IPD consists of five core databases, with the IMGT/HLA Database as the primary database. Through the work of the various nomenclature committees, the HLA Informatics Group and in collaboration with the European Bioinformatics Institute we are able to provide public access to this data through the website http://www.ebi.ac.uk/ipd/. The IPD project continues to develop with new tools being added to address scientific developments, such as Next Generation Sequencing, and to address user feedback and requests. Regular updates to the website ensure that new and confirmatory sequences are dispersed to the immunogenetics community, and the wider research and clinical communities.
Highlights
The Immuno Polymorphism Database (IPD) comprises a set of specialist databases related to the study of polymorphic genes in the immune system
Through the IPD project [1] we collaborate with specialist groups or nomenclature committees that provide and curate individual sections before they are submitted to IPD for online publication
IPD currently consists of five databases: IMGT/HLA, which contains sequences of the human Major Histocompatibility Complex (MHC); IPD-KIR, which contains the allelic sequences of the human Killer-cell Immunoglobulinlike Receptors; IPD-MHC, which is a database of sequences of the MHC of different species; IPD-HPA, which is a database of human platelet antigens; and IPD-European Searchable Tumour Line Database (ESTDAB), which provides access to the European Searchable Tumour Cell-Line Database, a cell bank of immunologically characterized melanoma cell lines
Summary
The Immuno Polymorphism Database (IPD) comprises a set of specialist databases related to the study of polymorphic genes in the immune system. The IPD project stores all the data in a set of related databases. A central function of the IPD project is as a database repository for the sequence data of polymorphic gene sequences. A variant cannot not be reported as a Single Nucleotide Polymorphism (SNP) at a single position compared to a reference, without submitting proof of the sequence, the methodology used to obtain the sequence and details of the sample and its source.
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