Abstract
IT IS NOW generally agreed that antithyroid drugs such as thiouracil prevent the formation of thyroid hormone. Astwood and Bissell (1944) found in rats that under the continuous influence of thiouracil the iodine content of the thyroid rapidly falls to low levels and that the thyroid gland simultaneously enlarges. Astwood (1944–45)showed that animals thus depleted of iodine are still able to concentrate rapidly considerable quantities of iodine when injected with potassium iodide. This iodine is not precipitated when the thyroid protein is denatured by heating. McGinty (1946) has noted that increasing the amount of dietary iodine raises the thyroid iodine content above the usual low levels in rats chronically treated with thiouracil.
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