Abstract
Until now involvement of the cerebral cortex in regulating leucocytic reactions was considered doubtful. However recent reports indicate that regulation is chiefly of a conditioned reflex nature. We have regarded the cerebral cortex as the organ mediating higher unconditioned reflex regulation of various bodily functions, and have demonstrated some features of this regulation. Redistributive leucocytic reactions were induced by an intravenous injection of a threshold insulin dose into decorticate and into intact dogs. The reduction of the threshold value of the insulin dose required to elicit the leucocytic response after decortication, and the greater duration of the leucopenia induced by the insulin injection led us to conclude that the unconditioned reflex arc which induces the redistributive leucocytic reaction has a humoral link.
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