Abstract
P16 The mechanisms responsible for the maintenance of chronic renovascular hypertension (RVH) remain undefined. Excess systemic or local generation of angiotensin II (AII) may lead to enhanced release of reactive oxygen radical species, vasoconstrictor activity, and parenchymal injury. To examine the potential involvement of oxidation-sensitive mechanisms, blood samples were collected from 7 RVH pigs with unilateral renal artery stenosis (achieved by a local-irritant stent) 5 and 10 weeks after induction of RVH, and from 7 normal pigs. Shock-frozen renal cortical tissue was analyzed post mortem. At 5 weeks after induction of RVH, plasma renin activity (PRA) was elevated in RVH pigs and correlated with an increase in MAP of 27±11% (r=0.85). PGF2 alpha isoprostanes, markers of oxidative status and potent vasoconstrictors, were also increased compared to normal (157±21 vs. 99±16 pg/mL, p
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