Abstract
The selective opioid δ-receptor antagonist, IC 154,129, attenuated the antinociception, assessed by prolongation of reaction time on the hot-plate, of mice which had swum for 3 min at 20°C. This stress-induced antinociception was also sensitive to naloxone suggesting the involvement of both δ- and μ-receptors. A swim of 0.5 min at 30°C did not produce antinociception on the hot plate but the writhing response to i.p. acetic acid was blocked by a non-opioid mechanism.
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