Abstract
Previous studies have described the die‐away phenomenon as a gradual, albeit progressive, reduction in skin blood flow following >60 min of local skin heating. We investigated the involvement of nitric oxide synthase (NOS) in this die‐away phenomenon. Participant forearms were instrumented with microdialysis fibers, local skin heaters, and laser‐Doppler probes. Skin sites were treated with either a saline solution (control) or the NOS inhibitor, Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME). Skin sites were heated from 33 to 41 °C at a rate of 0.5 °C · 10 s−1and held stable for 90 min. Baseline, initial peak, plateau, and die‐away phases were compared between sites. Both skin sites exhibited the characteristic biphasic response to local heating while also demonstrating a decrease in skin blood flow following an established plateau. L‐NAME treated sites were different across all measures (P<0.05). Importantly, the magnitude of the die‐away was reduced under conditions of L‐NAME treatment compared to control (P<0.05). These data suggest that NOS is involved in the die‐away phenomenon. Supported by The University of Alabama.
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