Abstract
A preferential agonist of dopamine D3 receptors, 7-hydroxy-N-N-di-n-propyl-2-aminotetralin (7-OH-DPAT), injected into the cerebellar lobules 9 and 10 (0.001-10 microg/0.5 microl) dose-dependently reduced locomotor activity of rats. 7-OH-DPAT injections into the lobule 8 were ineffective. The 7-OH-DPAT-induced hypolocomotion was inhibited by intracerebellar (0.9 microg/0.5 microl) or systemic (0.2 mg/kg sc) injection of a selective D3 receptor antagonist, (3aR,9bS)-N-[4-(8-cyano-1,3a,4,9b-tetrahydro-3H-benzopyrano[3,4-c]pyrrole-2-yl)-butyl]-(4-phenyl) benzamide (S33084). The present results indicate that dopamine D3 receptors in lobules 9 and 10 contribute to 7-OH-DPAT-induced hypolocomotion.
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