Abstract
1. Effects of W-7 and W-5, calmodulin antagonists, on the pigment aggregation within melanophores and coloring response of iridophores were examined in the blue damselfish, Chrysiptera cyanea. 2. W-7 was found to antagonize norepinephrine-induced responses of the chromatophores, whereas W-5 had only a slight effect on inhibition of the responses. 3. H-7, a specific antagonist of protein kinase C, did not arrest the responses of melanophores and iridophores at all. 4. The chromatophores responded normally to norepinephrine in Ca 2+, Mg 2+-free saline solution. 5. These results indicate that it is a Ca 2+/calmodulin-regulated enzyme and not protein kinase C that is involved in motile activities of fish chromatophores. Ca 2+ may be supplied from an intracellular store.
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