The involvement of an O2-derived nucleophilic species in acyl–carbon cleavage, catalysed by cytochrome P-45017α: implications for related P-450 catalysed fragmentation reactions

Abstract

The postulated iron peroxy species involved in acyl–carbon fission by 17α-hydroxylase-17,20-lyase (P-45017α) was trapped by an aldehyde analogue, partial 9, that was cleaved by the enzyme 10 times faster than the side-chain of the natural substrate 1.