Abstract
The present study investigated the effects of phencyclidine (PCP) on choice reaction in a 3-choice serial reaction time task for studying attentional function. PCP (3.2 mg/kg) significantly delayed choice reaction time and reduced choice accuracy. A novel σ receptor antagonist N, N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE-100) at 3.2 mg/kg, and 1-(cyclopropylmethyl)-4-[2′-(4″-fluorophenyl)-2′-oxoethyl]piperidine HBr (DuP734) at 1.0–3.2 mg/kg, but not 4-[2′-(4″-cyanophenyl)-2′-oxoethyl]-1-(cyclopropylmethyl)piperidine (XJ448), antagonized both the delayed choice reaction time and the decreased choice accuracy elicited by PCP administration. The antagonism induced by NE-100 was blocked by the σ receptor agonist (+)- N-allylnormetazocine HCl [(+)-SKF10,047]. These findings indicated that PCP (3.2 mg/kg) significantly induced attention deficit in a 3-choice serial reaction time task, and that this process may be mediated by σ receptors.
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