The investigations of bioactive copper(II) complexes with reduced low-molar dextran

Milorad Cakić,Žarko Mitić,Goran S Nikolić,Goran M Nikolić,Ljubomir Ilić

doi:10.1155/2008/754741

Abstract

The optimization of the reaction conditions (pH,T,t) to obtain stable copper(II) ion complexes with dextran derivatives were investigated in this paper. A complete synthesis of stable aqueous complexes can be realized with reduced low-molar polysaccharides, at an average molar mass 5000 g mol–1and pH 7.5–8. Fourier-transform IR spectra of polysaccharide dextran and its compounds with copper(II) ion, recorded at room temperature, were analyzed in order to obtain the information about the structure and the conformation of these polymer compounds. The ESR parameters of the spectra indicate the square-planar coordination of Cu(II) ion with four O atoms. Copper(II) complex formation with dextran and its derivatives were analyzed by physicochemical methods. Synthesized complexes of Cu(II) ion with reduced low-molar dextran in comparison with commercial preparations showed the considerably lower acute toxicity (LD501705).

Highlights

IntroductionEssential for living organisms. It is a hematopoetical active element [1] of some metaloenzymes regulating the iron absorption in intestines, maintaining, at the same time, the iron in a reduced state and influencing the iron incorporation into hemoglobin
Copper is a biometal, essential for living organisms
Synthesized Cu(II) complexes with reduced low molar dextran (RLMD) as a ligand differ in color, stability, solubility in water and conductivity

Summary

Introduction

Essential for living organisms. It is a hematopoetical active element [1] of some metaloenzymes regulating the iron absorption in intestines, maintaining, at the same time, the iron in a reduced state and influencing the iron incorporation into hemoglobin. Complex compounds of Cu(II) ion are important for prevention and treatment of some anemia caused by iron deficiency. The carbohydrate type compounds as ligands have been of a considerable interest Simple sugars and their derivatives with reduced and oxidized groups form metal ion complexes of a various composition and stability. In both human and veterinary medicine commercial copper preparations based on polysaccharide dextran and its derivatives are used for such purpose [3]. Synthesis procedures for the complex formation of Cu(II) ion with polysaccharides, including dextran, are described in scientific literature [14,15,16]. / The investigations of bioactive copper(II) complexes with reduced low-molar dextran Cakicet al. / The investigations of bioactive copper(II) complexes with reduced low-molar dextran

Spectroscopic and physicochemical characterization of complexes

Pharmacological testing

Results and discussion

Procedure

Conclusion