Abstract
A simple method for detecting minor (“mid-band”) liporoteins by electrophoresis in polyacrylamide gel is described. Using a technique based on that of Frings et al. [1] a number of fine bands (sometimes called mid-bands) are seen lying between the β- and the pre-β-lipoprotein. Of the most prominent bands one, labelled L.1 in Fig. 1, occurs immediately above the β-lipoprotein and one (central mid-band) occurs halfway between ordinary β-lipoprotein and pre-β-lipoprotein. Ultracentrifugation followed by electrophoresis in agarose gel showed that the band L.1 is probably due to sinking pre-β-lipoprotein. A preliminary survey to determine the frequency of these mid-band lipoproteins in normal sera and in sera from patients with ischaemic heart disease or hyperlipidaemia is presented. The central mid-band appears to be associated with hypertriglyceridaemia and the possibility that the sinking pre-β-lipoprotein is associated with ischaemic heart disease is not excluded.
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