The Investigation of Behavior Change in EEG Signals During Induction of Anesthesia

Abstract

Anesthesiology aims to make anesthesia safer and increase the precision of prognoses. Correct assessment of the anesthesia depth is crucial to its safety. At present, intraoperative electroencephalogram (EEG) monitoring is the primary mode of anesthesia depth monitoring and judgment. However, most clinical anesthesiologists rely on commercial anesthesia depth monitors to judge anesthesia depth, such as bispectral index (BIS) and patient state index (PSI). This may lack an understanding of associated changes in brain wave quantization. Therefore, this study conducts quantitative analyses of EEG signals during anesthesia induction. EEG signals are processed within specific time windows and extracted brainpower density spectrum arrays with different frequency bands, brain electrical signal spectra, source frequencies and other key indicators. Analysis and comparison of these indicators clarifies patterns of variation in EEG signals during early anesthesia induction. The spectral edge frequencies (SEFs) of EEG signals within different time windows can be modeled accurately, from which the specific time points of EEG signal changes are derived. Furthermore, the relationship between patient age and the effect of anesthetic drugs is preliminarily investigated by analyzing the SEF variations of different age groups. This study quantifies changes in the EEG signals of patients at the initial stage of anesthesia induction and drug-related effects are observed, which opens a way for further exploration of EEG changes in patients under general anesthesia.