Abstract
Abstract Objectives It was aimed to investigate if there were any significant corresponding changes on adipokine levels in obese subjects who achieved a 10% reduction in body weight. Methods Thirty obese and 25 healthy adults were enrolled in present study, and serum levels of vaspin, apelin-13, obestatin, and insulin were determined with the ELISA method. Results The serum obestatin and apelin-13 values of the obese group obtained as basal and after weight loss was significantly lower than in controls (p<0.05, p<0.01, p<0.01, p<0.05, respectively); however, weight loss did not cause significant changes on these parameters in obese groups (p>0.05). The vaspin level did not differ between the groups (p>0.05). The obese group had characterized increased serum insulin and insulin resistance assessment by the homeostatic assay (HOMA-IR) levels compared to controls (p<0.01, p<0.05, respectively); also, weight loss caused a significant decrease in these parameters compared to basal levels (p<0.01). No significant correlation was detected among the vaspin, apelin-13 and obestatin levels in the obese group (p>0.05). Conclusions Obese individuals exhibited decreased levels of apelin-13 and obestatin. Moreover, 10% weight loss caused a significant reduction of insulin resistance, but no significant change was detected on apelin-13, obestatin, and vaspin levels.
Highlights
Obesity, which occurs as a result of excessive accumulation of adipose tissue, is an important public health problem worldwide with social and psychological dimensions
The basal waist-to-hip ratio (WHR) of the obese group was higher at significant levels than in controls, but there was no significant difference after the weight loss (Table 1)
The serum obestatin and apelin-13 values of the obese group obtained at both basal (18.15 ± 7.60 ng/mL, 3.44 ± 1.38 ng/mL, respectively) and after weight loss (17.32 ± 6.36 ng/mL, 4.01 ± 1.20 ng/mL, respectively) were found to be significantly lower than the control group (22.93 ± 5.90 ng/mL, 4.78 ± 1.08 ng/mL, p
Summary
Obesity, which occurs as a result of excessive accumulation of adipose tissue, is an important public health problem worldwide with social and psychological dimensions. Being overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. Measurement of obesity is the body mass index (BMI), the weight of person (kg) divided by the square of height (in meters). The BMI of a person is classified as overweight when it is 25 kg/m2 and above and as obese when it is 30 kg/ m2 and above [3]. The prevalence of obesity varies from country to country and has increased worldwide [4]. Longterm epidemiological studies have shown that obesity is a significant risk factor and contributor to increased morbidity and mortality, most importantly for cardiovascular diseases (CVD), diabetes, cancer, chronic diseases, osteoarthritis, liver-kidney disease, sleep apnea, and depression [6, 7]
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