Abstract
The chemistry of ribonucleotides and other phosphates is extended to include their reactions with potassium fluoride in aqueous solution in the presence of a water soluble carbodiimide. High yields (>98%) of phosphorofluoridates are formed. A combination of HPLC, mass spectrometry, and NMR confirms the identities of the products. The methodology is applied, with equally satisfactory outcomes, to the physiologically active phosphonates Adefovir® and Tenofovir®, providing new compounds. Detailed NMR studies of the new phosphonofluoridates are reported.
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