The Intraperitoneal-Ketoprofen-Histopathological Induced Alterations in the Wistar Rat Kidneys

Abstract

The current-focused study was carried out to generate a data profile about expected changes that could be induced in the kidneys of rats due to the use of intraperitoneal ketoprofen (KP). The study involved using 24 adult male Wistar rats sorted randomly into four groups (six animals per group). One group was treated as a control group, C, which was supplied with distilled water (DW) only. The remaining animals were presented as (50KP), (25KP), or (12.5KP) groups that received 50mg/kg.b.w., 25mg/kg.b.w., or 12.5mg/ kg.b.w., respectively, of KP. The experiment was continued for 70 days, and the kidney tissue samples were collected from the scarified animals at the end of day 70 of that experiment. The kidney tissues of the 50KP animals revealed dilation of the tubules throughout the outer strip of the outer medulla with necrosis and sloughing of the epithelial cells of the proximal convoluted tubules (PCTs). However, the 25KP group suffered lesser grades of epithelial-cell sloughing of the PCTs with lower levels of dilation of tubules than those recorded in the 50KP group. On the other hand, the kidney tissues of the 12.5KP group showed only dilation in the PCTs. The present experimental data unveil the side effects generated by the use of the intraperitoneal KP in the examined rat kidneys which should be used as a launching set of information for better use or further study this drug and its side effects in human patients.