Abstract
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral vascular or pulmonary vascular diseases, etc.
Highlights
The guidelines of the European Society of Cardiology[1] recommend percutaneous coronary intervention (PCI) as the preferred strategy for reperfusion therapy in patients with acute ST-segment elevation myocardial infarction (STEMI)
There was no significant difference (P > 0.05) in sex, age, risk factors, Killip classification, infarction-related artery (IRA), time from onset to balloon dilatation, time from admission to balloon dilatation, number of dilated balloons used during surgery, number of stents implanted, intraoperative aortic balloon counterpulsation operations, and temporary pacemakers between the Pro-UK group and the control group [Table 1]
The following indexes of the two groups were analyzed: the Thrombolysis in Myocardial Infarction (TIMI) classification of the IRA immediately after surgery and the corrected TIMI frame count (CTFC) were used to assess the blood perfusion of culprit vessels; whether the ST segment had decreased by more than 50% at 90 min; and whether the peak of creatine kinase (CK)-MB and Cardiac troponin I (cTnI) had decreased by more than 50%
Summary
The guidelines of the European Society of Cardiology[1] recommend percutaneous coronary intervention (PCI) as the preferred strategy for reperfusion therapy in patients with acute ST-segment elevation myocardial infarction (STEMI). When the thrombus load in the coronary artery is heavy, PCI cannot effectively remove the thrombus and increases the risk of thrombus shedding, leading to the occurrence of “slow blood flow” and “no reflow” in the distal infarction-related artery (IRA). For STEMI patients with a high coronary artery thrombus load, the treatment strategy is critical, which has puzzled interventional doctors. The purpose of this study was to analyze the safety and efficacy of the intraoperative injection of recombinant human prourokinase (rhPro-UK) in STEMI patients with a high thrombus load during emergency PCI with IRA
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