Abstract
The population of trans and gender-diverse (TGD) people is undergoing two significant changes relevant to health professionals worldwide: (1) a significant increase in TGD people seeking gender-affirming medical treatment (GAMT),1 and (2) the diversification of genders (ie, nonbinary) and GAMT requests.2 Numerous studies have shown that the number of TGD people has increased over time: a recent systematic review found a range of 17 to 33 per 100 000 for TGD people presenting in clinical settings.3 At the same time, evidence gaps have shown up, because the group of treatment-seeking nonbinary people has little representation in previous studies.4 As of now, it remains unclear to what extent the increase in numbers also represents nonbinary people seeking treatment. However, in 2012, a paradigm shift took place with the publication of the 7th version of the Standards of Care (SoC7),5 opening up the guidelines for those identifying beyond the gender binary. This hypothetically lowered the threshold for access to care for nonbinary people requesting GAMT.2
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