Abstract
The effects of granule density and bulk density on tablet weight, weight variation, and tablet density were determined for tablets compressed on a Colton Model 216, rotary tablet press. Hardness, thickness, and disintegration times were also determined for the tablets produced. Standardized granulations were made from lactose and mixtures of lactose and bismuth subcarbonate, with gelatin as a binder. Granule density and bulk density of the granulations were varied by changing the concentrations of bismuth aubcarbonate in the formula. All tablets were made at a fixed rate of tableting using standardized settings of the fill, pressure, and overload adjustments. The interrelationship between granule density and bulk density was found to be almost linear, as was also the relationship between granule density, bulk density, and tablet weight.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
