THE INTERRELATION OF HYPERTENSION AND HYPERURICEMIA THE PRISM OF SCORE2

Abstract

Objective: Hyperuricemia increases the risk of hypertension. At the same time, hypertension is a part of the SCORE2 model, which assesses the total cardiovascular risk. In the present study, we analyzed the interrelation between the prevalence of hyperuricemia and the cardiovascular risk calculated with the SCORE2 model. Design and method: A total of 1603 Krasnoyarsk Krai inhabitants were recruited in the ESSE-RF study. The study protocol provided a standard questionnaire, anthropometry, office blood pressure measurement, and biochemical blood analyses to find the prevalence of known cardiovascular diseases and their risk factors. These data allowed us to calculate an individual cardiovascular risk with the SCORE2 model for each study participant. After that, we compared the prevalence of hyperuricemia (uric acid levels higher than 360 micromole/l in females and 400 micromole/l in males) in the low, medium, and high cardiovascular risk subgroups. Results: We found 30.7% (95% CI = 28.4%-33.0%) of the study participants having hyperuricemia. In persons aged 40 and older, 10.8% had a low risk, 37.0% had a medium risk, and 52.2% had a high cardiovascular risk, according to the SCORE2. In the low-risk subgroup, the prevalence of hyperuricemia was at 11.3% (95% CI = 5.3%-17.4%). At a medium risk, 27.0% (95% CI = 22.4%-31.6%) of people had hyperuricemia. Finally, in the subgroup of high risk, hyperuricemia was found in 37.0% (95% CI = 32.8%-41.2%) of people. Chi-square was for trend at p < 0.001. Conclusions: Due to the interrelations between hypertension and hyperuricemia, the higher is the SCORE2-calculated cardiovascular risk of a patient, the higher is the probability that this patient also has hyperuricemia.