Abstract
This scoping review aims to clarify the interplay between obesity, vitamin D deficiency, cellular senescence, and obesity-related metabolic consequences, mainly subclinical atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Obesity is a significant global health problem that involves cellular, environmental, behavioral, and genetic elements. The fundamental cause of obesity throughout all life stages is an energy imbalance, and its consequences are countless and, foremost, very common. Obesity has been comprehensively studied in the literature given its association with low serum vitamin D, with many proposed mechanisms linking the two conditions. Moreover, markers of exaggerated cellular senescence have been proven to accumulate in obese individuals. Subclinical atherosclerosis initiates an early stage that ends in serious cardiac events, and obesity, low vitamin D, and senescent cells largely contribute to its associated chronic low-grade inflammation. Furthermore, NAFLD signifies the hepatic manifestation of metabolic syndrome, and studies have highlighted the important role of obesity, vitamin D deficiency, and cellular senescence in its development. Therefore, we outlined the most important mechanisms tying these conditions to one another.
Highlights
Years of research have revealed the association of three conditions with the development of subclinical atherosclerosis and non-alcoholic fatty liver disease (NAFLD): obesity, vitamin D deficiency (VDD), and cellular senescence
We reviewed published articles that discussed obesity-related disorders, subclinical atherosclerosis and NAFLD, and their correlation with VDD and cellular senescence
We emphasized the interplay between obesity, VDD, and cellular senescence as pathophysiological mechanisms that play a role in subclinical atherosclerosis and NAFLD
Summary
Years of research have revealed the association of three conditions with the development of subclinical atherosclerosis and non-alcoholic fatty liver disease (NAFLD): obesity, vitamin D deficiency (VDD), and cellular senescence. A wide spectrum of liver disorders is associated with obesity, including NAFLD, which is emerging as a serious health problem due to its potential to progress to end-stage liver cirrhosis [6]. This scoping review aims to discuss obesity, VDD, and cellular senescence and the possible mechanisms by which they contribute to the occurrence and progression of subclinical atherosclerosis and NAFLD
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.