Abstract
The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recognized as opposed to 1 of 30 peptides seen when gD was injected in Freund's adjuvant. This has also been seen in the response to local autoantigens when the HSV infection is produced by corneal scarification. Furthermore, analysis of the response to the autoantigen, Golli myelin basic protein (MBP), present in the developing thymus is explored.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
