The Interplay between the Hippocampus and Amygdala in Regulating Aberrant Hippocampal Neurogenesis during Protracted Abstinence from Alcohol Dependence

Chitra D Mandyam

doi:10.3389/fpsyt.2013.00061

Abstract

The development of alcohol dependence involves elevated anxiety, low mood, and increased sensitivity to stress, collectively labeled negative affect. Particularly interesting is the recent accumulating evidence that sensitized extrahypothalamic stress systems [e.g., hyperglutamatergic activity, blunted hypothalamic-pituitary-adrenal (HPA) hormonal levels, altered corticotropin-releasing factor signaling, and altered glucocorticoid receptor signaling in the extended amygdala] are evident in withdrawn dependent rats, supporting the hypothesis that pathological neuroadaptations in the extended amygdala contribute to the negative affective state. Notably, hippocampal neurotoxicity observed as aberrant dentate gyrus (DG) neurogenesis (neurogenesis is a process where neural stem cells in the adult hippocampal subgranular zone generate DG granule cell neurons) and DG neurodegeneration are observed in withdrawn dependent rats. These correlations between withdrawal and aberrant neurogenesis in dependent rats suggest that alterations in the DG could be hypothesized to be due to compromised HPA axis activity and associated hyperglutamatergic activity originating from the basolateral amygdala in withdrawn dependent rats. This review discusses a possible link between the neuroadaptations in the extended amygdala stress systems and the resulting pathological plasticity that could facilitate recruitment of new emotional memory circuits in the hippocampus as a function of aberrant DG neurogenesis.

Highlights

The development of alcohol dependence involves elevated anxiety, low mood, and increased sensitivity to stress, collectively labeled negative affect
NEUROGENESIS IN THE ADULT DENTATE GYRUS Accumulating evidence over the past four decades shows that forebrain neural stem cells populate two main areas, the subventricular zone of the lateral ventricles and subgranular zone (SGZ) of the hippocampal dentate gyrus (DG; Figure 1), where they give rise to neurons throughout adulthood
The process of neurogenesis involves stem-like precursor cells that proliferate into preneuronal progenitors, which in turn differentiate into immature neurons and eventually mature into granule cell neurons (GCNs; Kempermann et al, 2004; Abrous et al, 2005; Figure 1)

Summary

Introduction

The development of alcohol dependence involves elevated anxiety, low mood, and increased sensitivity to stress, collectively labeled negative affect. ALCOHOL EXPOSURE PRODUCES NEUROTOXICITY AND EXCITOTOXICITY IN THE HIPPOCAMPUS Using the in vitro organotypic hippocampal cell culture model, it has been demonstrated that hippocampal CA1 excitotoxicity is evident after withdrawal from chronic ethanol exposure and not during ethanol exposure (Mulholland et al, 2003; Prendergast et al, 2004; Wilkins et al, 2006).

Results

Conclusion