Abstract
The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.
Highlights
The most prominent and popular aspect of adeno-associated virus (AAV) is its use in gene therapy with over 200 currently ongoing clinical trials.in this review, we focus on another, fascinating aspect: the interplay betweenassociated viruses (AAVs), its helper viruses, and the impact on the coinfected host cell
We first outline the biology of AAV, herpes simplex virus type 1 (HSV-1), and adenoviruses (AdVs), followed by the exploration of the interactions between AAV and its helper viruses
As the genus name suggests, AAV can only replicate in the presence of helper factors, which are provided by coinfections by helper viruses from the herpesvirus family (e.g., HSV-1 and human cytomegalovirus, HCMV), adenoviruses (e.g., adenovirus type 5 (AdV5)), and papillomaviruses, as well as other viruses such as baculovirus and human bocavirus 1 [1,8,9,10,11,12]
Summary
The most prominent and popular aspect of adeno-associated virus (AAV) is its use in gene therapy with over 200 currently ongoing clinical trials (http://www.abedia.com/wi-ley/vectors.php). In this review, we focus on another, fascinating aspect: the interplay between. AAV, its helper viruses, and the impact on the coinfected host cell. We first outline the biology of AAV, herpes simplex virus type 1 (HSV-1), and adenoviruses (AdVs), followed by the exploration of the interactions between AAV and its helper viruses. The role of AAV in gene therapy is briefly discussed at the end
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