Abstract
The establishment of the International Consensus on ANA Patterns (ICAP) in 2014-2015 was welcomed by members of the medical community as a significant improvement in guiding harmonization of ANA test interpretation and reporting. In the subsequent years, several itinerant meetings and continuous interaction with the community contributed to disseminate the ICAP harmonization on the immunofluorescence patterns observed in the indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA) and to promote progressive improvement in the classification of HEp-2 IFA patterns. The 6th ICAP Workshop was held in person on September 6, 2021 as a satellite meeting of the 15th Dresden Symposium on Autoantibodies. This article summarizes the major discussions at the meeting as well as outlining the current plans for the ICAP committee.
Highlights
The Autoantibody Standardization Committee (ASC) has identified 23 reference reagents that are available free of charge to research laboratories, diagnostic laboratories, and commercial organizations developing autoantibody diagnostic kits via the ASC website and are distributed by the Plasma Services Group on a not-for-profit basis. Another achievement of the ASC is the establishment of the International Consensus on antinuclear antibodies (ANA) Patterns (ICAP) initiative during the 12th International Workshop on Autoantibodies and Autoimmunity held in Sa~o Paulo, Brazil in 2014 [2]
Since the first ICAP Workshop, 30 different HEp2 immunofluorescence assay (IFA) patterns have been categorized into 4 major groups: negative (n 1⁄4 1), nuclear (n 1⁄4 15), cytoplasmic (n 1⁄4 9), and mitotic patterns (n 1⁄4 5) [2, 3, 5, 7, 8]
The resulting consensus nomenclature was arranged into a classification tree that is displayed on the ICAP website
Summary
Another achievement of the ASC is the establishment of the International Consensus on ANA Patterns (ICAP) initiative during the 12th International Workshop on Autoantibodies and Autoimmunity held in Sa~o Paulo, Brazil in 2014 [2]. Since the first ICAP Workshop, 30 different HEp2 IFA patterns have been categorized into 4 major groups: negative (n 1⁄4 1), nuclear (n 1⁄4 15), cytoplasmic (n 1⁄4 9), and mitotic patterns (n 1⁄4 5) [2, 3, 5, 7, 8].
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