Abstract
Interleukin-10 (IL-10) is a multifunctional cytokine which participates in the development and progression of various malignant tumors. To date, a number of case–control studies were conducted to detect the association between IL-10-592C>A polymorphism and cancer risk in humans. However, the results of these studies on the association remain conflicting. In an effort to solve this controversy, we performed a meta-analysis based on 70 case–control studies from 65 articles, including 16 785 cancer cases and 19 713 controls. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall results suggested that the variant homozygote genotype AA of the IL-10-592C>A polymorphism was associated with a moderately decreased risk of all cancer types (OR = 0.90, 95% CI = 0.83–0.98 for homozygote comparison, OR = 0.92, 95% CI = 0.86–0.98 for recessive model). In the stratified analyses, the risk remained for studies of smoking-related cancer, Asian populations and hospital-based studies. These results suggested that the IL-10-592C>A polymorphism might contribute to the cancer susceptibility, especially in smoking-related cancer, Asians and hospital-based studies. Further studies are needed to confirm the relationship.
Highlights
Cancer is a major public health problem in the world
The present meta-analysis investigated the association between the IL-10-592C.A polymorphisms and cancer risk, based on 70 published case–control studies from 65 articles
The results provided evidence that the IL-10-592C.A polymorphism was associated with a significant decrease in overall cancer risk
Summary
Cancer is a major public health problem in the world. Evidences support an important role for genetics in determining risk for cancer. Interleukin-10 (IL-10) is a multifunctional cytokine which participate in the development and progression of various malignant tumors [2]. It has anti-inflammatory and immunosuppressive activities including the ability to downregulate the expression of macrophage costimulatory molecule. The impact of IL-10 on macrophage function appears to play a role in the growth of blood vessel, as studies showed that IL-10 might contribute to the regulation of angiogenesis in many kinds of tumors [3,4]. As an immunosuppressive molecule allowing tumor to escape from immune surveillance, IL-10 might act as a potential tumor promoter which results in a more aggressive behavior of malignant cells. Due to its immune-stimulating and anti-angiogenic properties, IL-10 is supposed to prevent or reduce the growth and distant spread of tumor [5–7].It has been indicated that IL-10 overexpression as well as deficiency was found under different pathophysiological conditions depending on the cancers analyzed [8]
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