The interferon production and 2',5'-oligoadenylate-synthetase activity in rat spleen lymphocytes at hypoacidity evoked by omeprazole injectionand at administration of multiprobiotic "SYMBITER"

Abstract

The IFN production by rat spleen lymphocytes was shown to increase by 2.5 times in comparison to control against a background of hypoacidity evoked by 28-days of OM treatment (14 mg/kg). The activity of IFN-induced enzyme 2',5'-OAS declined by 16 % in these cells. The simultaneous administration of multiprobiotic SYM and OM resulted in IFN titer increase in comparison to hypoacidic animals. The 2',5'-OAS activity in spleenocytes didn’t change. SYM displayed interferonogenic properties via gastric microflora normalization and suppressing inflammation.