The Interferon-Inducible, Double-Stranded RNA-Specific Adenosine Deaminase Gene (DSRAD) Maps to Human Chromosome 1q21.1–21.2

Abstract

The interferon-inducible double-stranded RNA-specific adenosine deaminase is an RNA-modifying enzyme implicated in the generation of biased hypermutations of viral RNAs and the site-selective editing of mammalian mRNAs of neural origin. The gene for the dsRNA-specific adenosine deaminase has been mapped by fluorescencein situhybridization (FISH) of genomic clones to a single locus on human chromosome 1 bands q21.1–21.2. Simultaneous multicolor FISH including λ clones and yeast artificial chromosomes showed a localization of the gene in band 1q21 centromeric of D1S1705.