Abstract
The pharmaceutical clay montmorillonite (MMT) is, for the first time, explored as a carbon monoxide-releasing material (CORMat). MMT consists of silicate double layered structure; its exfoliation feature intercalate the CORM-2 [RuCl(μ-Cl)(CO)3]2 inside the layers to suppress the toxicity of organometallic segment. The infrared spectroscopy (IR) confirmed the existence of ruthenium coordinated carbonyl ligand in MMT layers. The energy-dispersive X-ray spectroscopy (EDX) analysis showed that ruthenium element in this material was about 5%. The scanning electron microscopy (SEM) and transmission electron microscope (TEM) images showed that the layer-structure of MMT has been maintained after loading the ruthenium carbonyl segment. Moreover, the layers have been stretched out, which was confirmed by X-ray diffraction (XRD) analysis. Thermogravimetric (TG) curves with huge weight loss around 100–200 °C were attributed to the CO hot-release of ruthenium carbonyl as well as the loss of the adsorbed solvent molecules and the water molecules between the layers. The CO-liberating properties have been assessed through myoglobin assay. The horse myoglobin test showed that the material could be hydrolyzed to slowly release carbon monoxide in physiological environments. The half-life of CO release was much longer than that of CORM-3, and it has an excellent environmental tolerance and slow release effect.
Highlights
Carbon Monoxide (CO) has a notorious reputation for being silent killer and life-threatening element for living organisms because of its colorless, odorless, and poisonous nature [1]
Using X-Ray Diffraction (X-ray) we found the diffraction of montmorillonite, Ru@MMT-1 and Ru@MMT-2; the characteristic peaks at 5.7 and
The Thermogravimetric Analysis (TGA) characterization of Ru@MMT-1 and Ru@MMT-2 showed a decrease in mass with increases in temperature, and the weight loss was greater at the initial stage due to solvent volatilization, loss of coordination water and cleavage of Ru-CO bond, and their corresponding weight loss rate were 15.5% and 12.1% respectively (Figure 7)
Summary
Carbon Monoxide (CO) has a notorious reputation for being silent killer and life-threatening element for living organisms because of its colorless, odorless, and poisonous nature [1]. The TGA characterization of Ru@MMT-1 and Ru@MMT-2 showed a decrease in mass with increases in temperature, and the weight loss was greater at the initial stage due to solvent volatilization, loss of coordination water and cleavage of Ru-CO bond, and their corresponding weight loss rate were 15.5% and 12.1% respectively (Figure 7). The TGA describes that the adsorbed content decreased under the temperature gradient and explains the temperature limit of the reaction This figure helps to understand the temperature profile of Ru@MMT-1 and Ru@MMT-2 too. It can be observed that solvent molecules have been adsorbed inside the layers of MMT, which is confirmed in corresponding to the XRD results. It can be observed that solvent molecules have 8boefe1n6 adsorbed inside the layers of MMT, which is confirmed in corresponding to the XRD results. STc-i.12a01n9d, 2R0,ux@MMT-2 has a greater half-life, indicating that MMT has excellent sustained10eofffe1c7t
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