Abstract
SummaryThe binding properties of yttrium with a variety of organic compounds have been investigated using an ion-exchange resin. EDTA had the greatest affinity, then citrate, isocitrate and malate, the binding being less at lower ph values. Serum albumin showed some binding, which decreased after hydrolysis with 6 N HC1 at 100°c. EDTA and citrate had far weaker chelating properties with 89Sr than 91Y. Extracts prepared from cortical beef-bone powder were found to possess only weak binding with yttrium, which decreased on dialysing the extract. If untreated bone powder was used in place of resin, the uptake of 91Y and 89Sr was less at the lower ph values. If the bone powder was ashed, 89Sr-uptake was unaffected, but 91Y-uptake was high at all ph values. It is suggested that citrate may be a factor determining the uptake of yttrium in bone.
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