Abstract
The effect of Drosophilamutation rad201G1together with mutations mei-41D5and mei-9aon the sensitivity of oocytes to induction of dominant lethals (DLs) was studied. To this end, the frequencies of spontaneous and gamma-radiation-induced DLs in consecutive egg batches of females carrying double or single mutations were estimated. Since the effects of the mutations examined are expressed only at the previtellogenetic stages of oogenesis, only newly hatched (0–5-hour-old) females, whose oocytes did not develop farther than stage 7, were irradiated. The results obtained indicated that in intact and irradiated oocytes of double mutants mei-9arad201G1and mei-41D5rad201G1, mutation rad201G1epistatically suppresses the mutations of the both meigenes.
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